SG Information

Hepeviridae Study Group

The Hepevirdae study group intends to post genome alignments of genera and species within the family in the near future.

The Table below gives a summary of the current taxonomic structure of the Hepeviridaeas as proposed in: Smith, D. B., Simmonds, P., Jameel, S., Emerson, S. U., Harrison, T. J., Meng, X.-J., Okamoto, H., Van der Poel, W. H. M. & Purdy, M. A. (2014). Consensus proposals for classification of the family Hepeviridae. J Gen Virol 95, 2223–32 and ratified by the ICTV.


Genus Species Genotype Prototype/Reference Strain Predominant Host Species GenBank Accession
Orthohepevirus Orthohepevirus A HEV-1 Burma Human M73218
    HEV-2 Mexico Human M74506
    HEV-3 Meng Human, pig, rabbit, deer, mongoose AF082843
    HEV-4 T1 Human, pig AJ272108
    HEV-5 JBOAR135-Shiz09 Wild boar AB573435
    HEV-6 wbJOY_06 Wild boar AB602441
    HEV-7 DcHEV-178C Camel KJ496143
  Orthohepevirus B    F93-5077 Chicken AY535004
  Orthohepevirus C HEV-C1 R63 Rat GU345042
    HEV-C2 FRHEV4 Ferret JN998606
  Orthohepevirus D    HEV/BS7/GE/2009 Bat JQ001749
Piscihepevirus Piscihepevirus A    Heenan Lake Trout HQ731075

An alignment of concatenated ORF1 and ORF2 amino acid sequences of Orthohepevirus species is available in FASTA and SSE formats.

Reference sequences for subtypes of Orthohepvirus A have been proposed in: Smith, D. B., Simmonds, P., Izopet, J., Oliveira-Filho, E. F., Ulrich, R. G., Johne, R., Koenig, M., Jameel, S., Harrison, T. J., Meng X-J., Okamoto H., van der Poel W.H.M. and Purdy M.A. (2016). Proposed reference sequences for Hepatitis E virus subtypes. J Gen Virol. 97: 537-542 (doi: here.

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