Syr-Darya Valley fever virus

This virus is included in the human virus database provided by Geoghagen et al. 2016 and is described in L'vov et al. 2014. I have not found any information on the ICTV taxonomic database/reports or the ArboCat from CDC. Any info on this virus, and why it is not included? If isolated from human blood and pathogenic, I would imagine this is important virus to cover. 

Geoghegan, J. L., Senior, A. M., Di Giallonardo, F., & Holmes, E. C. (2016). Virological factors that increase the transmissibility of emerging human viruses. Proceedings of the National Academy of Sciences113(15), 4170-4175.

L'vov, D. K., Al'khovskiÄ­, S. V., Shchelkanov, M., Shchetinin, A. M., Deriabin, P. G., Gitel'man, A. K., ... & Botikov, A. G. (2014). Genetic characterization of the Syr-Darya valley fever virus (SDVFV)(Picornaviridae, Cardiovirus) isolated from the blood of the patients and ticks Hyalomma as. asiaticum (Hyalomminae), Dermacentor daghestanicus (Rhipicephalinae)(Ixodidae) and Ornithodoros coniceps (Argasidae) in Kazakhstan and Turkmenistan. Voprosy virusologii59(4), 15-19.

  • Syr-Darya Valley fever virus (SDVFV) and Sikhote-Alin virus (SAV) were apparently isolated from humans and ticks and from ticks taken from wild boars, respectively. The were originally described as being serologically related to each other and to Mengo virus (a strain of EMCV) by complement fixation, but distinct from each other by virus neutralization. As far as I am aware, both viruses were only isolated in mice. The paper published by L'vov et al. (2014) describes the sequence of SDVFV as being most closely related to Theiler's murine encephalomyelitis virus (TMEV; species Cardiovirus B). However, the accession number given in the paper refers to SAV! This sequence is clearly a strain of TMEV. I presume that SDVFV as described in the publication is also a TMEV. It is possible that these viruses were already in the mice used for virus isolation, as is suspected for the TMEV-related Vilyuisk human encephalomyelitis virus (VHEV). More evidence is required to prove a link with human, pigs and ticks. The evidence as presented in the L'vov et al. (2014) (SDVFV) and the sequence of SAV (KJ191558) clearly show them to belong to the species Cardiovirus B.

Reply Children
No Data