Genus: Avisivirus

Genus: Avisivirus

Distinguishing features

The genus is distinguished on the basis of genetic characters.

Virion

Morphology

No details are available on the morphology of virions.

Physicochemical and physical properties

Unknown.

Nucleic acid

Genome (Lau et al., 2014): c. 7,530 nt (5′-UTR: 548; ORF: 6,498–6,720; 3′-UTR: 264 nt). The 5′-UTR contains a type II IRES. The location of the cre has not been identified.

Genome organization and replication

Genome layout:

VPg+5′-UTRIRES-II-[1AB-1C-1D-(2A1npgp)/2A2npgp/2A3NTPase-2A4H-box/NC-2B-2C/3A-3B-3C-3D]-3′-UTR-poly(A)

The deduced polyprotein is of 2,165–2,239 amino acids. There is no L protein. The 1AB protein remains uncleaved. Avisiviruses have three to four 2A proteins, i.e. one or two short foot-and-mouth disease virus-like (2A1 and 2A2) with an NPG↓P motif, 2A3 with an AIG1-type guanine nucleotide-binding domain (GxxGxGKS NTP-binding motif) and 2A4 with an H-box/NC motif.

Biology

No virus has been isolated.Viral RNA was detected in faeces of turkeys (Meleagris gallopavo) and chickens (Gallus gallus domesticus) with gastrointestinal disease. Four types are distinguished by means of phylogenetic clustering (AsV-A1, AsV-B1, AsV-C1, -C2).

Derivation of names

Avisivirus-: from Avihepato sister-clade

Species demarcation criteria

Members of a species of the genus Avisivirus:

  • share an essentially identical genome organization
  • are less than 40% divergent in P1 aa sequence
  • are less than 30% divergent in 2C + 3CD aa sequence

The divergence (number of differences per site between sequences) between members of different Avisivirus species ranges from 0.53–0.59 for P1 and 0.46–0.49 for 3CD.

Member species

Exemplar isolate of the species
SpeciesVirus nameIsolateAccession numberRefSeq numberAvailable sequenceVirus Abbrev.
Avisivirus Aavisivirus A1USA-IN1KC614703NC_038304Complete genomeAsV-A1
Avisivirus Bavisivirus B1; chicken picornavirus 244CKF979333NC_024766Complete genomeASV-B1
Avisivirus Cavisivirus C1; chicken picornavirus 345CKF979334NC_024767Complete genomeAsV-C1

Virus names, the choice of exemplar isolates, and virus abbreviations, are not official ICTV designations.