Genus: Rosavirus

Genus: Rosavirus

Distinguishing features

The genus is distinguished on the basis of genetic characters. 



No details are available on the morphology of virions. 

Nucleic acid

Genome (Phan et al., 2011, Lim et al., 2014, Du et al., 2016Lau et al., 2016): c. 8,931 nt (5′-UTR: 504–721 nt; ORF: 7,410–7,449 nt; 3′-UTR: 712–946 nt). The 5′-UTR harbours a type II IRES. The 3′-UTR is the longest of picornaviruses. The location of the cre has not been identified.

Genome organization and replication

Genome layout:


The deduced polyprotein is of 2,468–2,491 aa. 2A has an H-box/NC motif. 


No virus has been isolated. Viral RNA was detected in faecal samples of humans and rodents [canyon mouse (Peromyscus crinitus), brown rat (Rattus norvegicus), black rat (R. rattus), Sikkim rat (R. andamanensis), chestnut white-bellied rat (Niviventer fulvescens)]. Eight genetic types are distinguished by means of phylogenetic analysis (Rosavirus A: 2 types; Rosavirus B: 2 types; Rosavirus C: 4 types).

Derivation of names

Rosavirus: from rodent stool-associated virus

Species demarcation criteria

Members of a species of genus Rosavirus:

  • share a common genome organization
  • are less than 30% divergent in the polyprotein aa sequence
  • are less than 30% divergent in the P1 aa sequence
  • are less than 25% divergent in the 2C + 3CD aa sequence

Member species

Exemplar isolate of the species
SpeciesVirus nameIsolateAccession numberRefSeq numberAvailable sequenceVirus Abbrev.
Rosavirus Arosavirus A1mouse/USA/M-7/2010JF973686NC_038880Complete coding genomeRoV-A1
Rosavirus Arosavirus A2hu/GA7403/Gambia/2008KJ158169Complete genomeRoV-A2
Rosavirus Brosavirus B1; Norway rat rosavirusRNCW0602091RKX783423NC_031105Complete genomeRoV-B1
Rosavirus Brosavirus B2; Norway rat rosavirusNrRV/NYC-A15KJ950906; KJ950911Partial genomeRoV-B2
Rosavirus Crosavirus C1; rat rosavirusRASK8FKX783424Complete genomeRoV-C1
Rosavirus Crosavirus C2RATLC11AKX783425Complete genomeRoV-C2
Rosavirus Crosavirus C3NCGX12INKX783432Complete genomeRoV-C3
Rosavirus Crosavirus C4rodent/RL/PicoV/FJ2015KX156156Complete genomeRoV-C4

Virus names, the choice of exemplar isolates, and virus abbreviations, are not official ICTV designations.