Genus: Rabovirus

Genus: Rabovirus

Distinguishing features

The genus is distinguished on the basis of genetic characters.

Virion

Morphology

No details are available on the morphology of virions.

Nucleic acid

Genome (Luo et al., 2018, Williams et al., 2018Wu et al., 2018): up to 7,834 nt (5′-UTR: up to 751 nt; ORF: 6,930–7,143 nt; 3′-UTR: 61–91 nt). The location of the cre has not been identified. 

Genome organization and replication

Genome layout:

VPg+5′-UTRIRES-II-[L-1A-1B-1C-1D/2Apro-2B-2C/3A-3B-3C-3D]-3′-UTR-poly(A)

The deduced polyprotein ranges from 2,310 to 2,381 aa. The L protein has unknown function. The 2A protein has been proposed to be a chymotrypsin-like protease. 

Biology

No virus has been isolated. Viral RNA was detected in faeces of Norway rats (Rattus norvegicus) and mice (Mus musculus) in USA and Germany, in intestinal contents of Himalayan marmots (Marmota himalayana), and in tissue samples of Gairdner's shrewmice (Mus pahari). 

At least 6 genetic types are distinguished by means of phylogenetic analysis: Rabovirus A (2 types), Rabovirus B (1 type), Rabovirus C (1 type), Rabovirus D (2 types).

Derivation of names

Rabovirus: from rat-borne

Species demarcation criteria

Members of a species of genus Rabovirus:

  • share a common genome organization
  • are less than 30% divergent in the polyprotein aa sequence
  • are less than 30% divergent in the P1 aa sequence
  • are less than 25% divergent in the 2C + 3CD aa sequence

Member species

Exemplar isolate of the species
SpeciesVirus nameIsolateAccession numberRefSeq numberAvailable sequenceVirus Abbrev.
Rabovirus Arabovirus A1Berlin/Jan2011/0572KP233897NC_026314Complete genomeRaBoV-A1
Rabovirus Arabovirus A2Wencheng-Rn449MF352425Complete genomeRaBoV-A2
Rabovirus Arabovirus A3RPV/NYC-B10KJ950883Complete genomeRaBoV-A3
Rabovirus Arabovirus A4Wencheng-Rt38-1MF352417Complete genomeRaBoV-A4
Rabovirus Arabovirus A5Ruian-Rn93-2MF352408Complete genomeRaBoV-A5
Rabovirus Brabovirus B1RtMp-PicoV/YN2014KY432926Complete genomeRaBoV-B1
Rabovirus Crabovirus C1HT5KY855432NC_040605Complete genomeRaBoV-C1
Rabovirus Drabovirus D1MPV/NYC/2014/M005/0074MF175072Complete genomeRaBoV-D1

Virus names, the choice of exemplar isolates, and virus abbreviations, are not official ICTV designations.