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Similar to comoviruses, sadwaviruses have two CPs, one large and one small. The genome of sadwaviruses is bipartite and the genomic organization is similar to that of comoviruses. The proteinase of sadwaviruses is distinct from that of other viruses in the family in that it does not have a conserved His or Leu in the active site. In addition, the cleavage sites recognized by sadwavirus proteinases are unique with an A or a T at the -1 position (Table 3). In contrast to comoviruses, there is no evidence that two overlapping polyproteins are encoded by RNA-2. Similar to some nepoviruses, extensive sequence identity between RNA-1 and RNA-2 are found in the 5ʹ UTRs as well as in the 5ʹ end of the putative coding region.
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