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Length of genome (Lau et al., 2014): c. 7,530 nt (5'-UTR: 548; ORF: 6,498-6,720; 3'-UTR: 264 nt). 5' UTR contains a type II IRES. The location of the cre has not been identified.
Genome layout: VPg+5'UTRIRES-II[1AB-1C-1D-(2A1npgp)/2A2npgp/2A3NTPase-2A4H-box/NC-2B-2C/3A-3B-3C-3D]3'UTR-poly(A)
The deduced polyprotein has a length of 2,165-2,239 amino acids. There is no L protein. The 1AB protein remains uncleaved. Avisiviruses have three to four 2A proteins, i.e. one or two short FMDV-like (2A1 and 2A2) with NPG¯P motif, 2A3 with P-loop NTPase sequence motifs and 2A4 with H-box/NC motif.
Viral RNA was detected in faeces of turkeys (Meleagris gallopavo) and chickens (Gallus gallus domesticus) with gastrointestinal disease.
Members of a species of the genus Avisivirus share a common genome organization.
The divergence (number of differences per site between sequences) of known Avisivirus species ranges from 0.53-0.59 for P1 and 0.46-0.49 for 3CD. Four types have been classified by means of phylogenetic clustering (AsV-A1, AsV-B1, AsV-C1, -C2).
Avisi-: from Avihepato sister-clade
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