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The genus is distinguished on the basis of genetic characters.
No surface morphology is visible by EM.
Virions are stable at acid pH. Buoyant density in CsCl is 1.33 g cm-3. Empty capsids are often observed in virus preparations.
Genome (Zell et al., 2001, Buitrago et al., 2010, Boros et al., 2012b, Yang et al., 2018, Oba et al., 2018): >7,110 nt (5′-proximal sequence missing) (5′-UTR: >335 nt; ORF: 6,600–6,711; 3′-UTR: 67 nt). Teschoviruses have a type IV IRES of about 290 nt which is functional in the absence of eIF-4G. The location of the cre is thought to be within the 2C region.
The deduced polyprotein varies from 2,199–2,236 aa. The function of the leader polypeptide is unknown. 2A is a short polypeptide with an NPG↓P motif.
Clinical manifestations may include a polioencephalomyelitis (“Teschen/Talfan disease”, also known as teschovirus encephalomyelitis), which may vary in severity. The viruses have been associated with a number of disease syndromes, including reproductive and gastrointestinal disorders. Domestic pigs and wild boars are the only known hosts. Natural inter-species recombination has been described. Nineteen genetic types are distinguished by means of phylogenetic analysis (Teschovirus A: teschovirus A1 to -A14, Teschovirus B: teschovirus B1 to -B3; recombinant viruses: teschovirus A15CP-BPol, teschovirus A16CP-BPol).
Porcine teschoviruses are divided into 13 types (PTV-1 to -13) which are distinct in cross-neutralization tests (where tested).
Teschovirus: from Teschen disease; named after the Moravian-Silesian town Teschen (now Těšín at the Czech/Polish border.
Members of a species of the genus Teschovirus:
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