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No surface morphology is visible by EM.
Virions are stable at acid pH. Buoyant density in CsCl is 1.33 g cm-3. Empty capsids are often observed in virus preparations.
Length of genome (Zell et al., 2001, Buitrago et al., 2010, Boros et al., 2012b): >7,110 nt (5'-proximal sequence missing) (5'-UTR: >335 nt; ORF: 6,600-6,711; 3'-UTR: 67 nt). Teschoviruses have a type IV IRES about 290 nt in length which is functional in the absence of eIF-4G. The location of the cre is thought to be within the 2C region.
The deduced polyprotein vary in length from 2,199-2,236 aa. The function of the leader polypeptide is unknown and is not predicted to have proteolytic activity. 2A is a short FMDV-like polypeptide with NPG↓P motif.
Porcine teschoviruses are divided into 13 types (PTV-1 to -13) which are distinct in cross-neutralization tests (where tested).
Clinical manifestations may include a polioencephalomyelitis (“Teschen/Talfan disease”, also known as teschovirus encephalomyelitis), which may vary in severity. The viruses have been associated with a number of disease syndromes, including reproductive and gastrointestinal disorders. Domestic pigs and wild boars are the only known hosts.
Tescho: from Teschen disease, named after the Moravian-Silesian town Teschen (now Těšín at the Czech/Polish border).
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