Genus: Teschovirus


Genus: Teschovirus

Distinguishing features

The genus is distinguished on the basis of genetic characters.

Virion

Morphology

No surface morphology is visible by EM.

Physicochemical and physical properties

Virions are stable at acid pH. Buoyant density in CsCl is 1.33 g cm-3. Empty capsids are often observed in virus preparations.

Nucleic acid

Genome (Zell et al., 2001, Buitrago et al., 2010, Boros et al., 2012b): >7,110 nt (5′-proximal sequence missing) (5′-UTR: >335 nt; ORF: 6,600–6,711; 3′-UTR: 67 nt). Teschoviruses have a type IV IRES of about 290 nt which is functional in the absence of eIF-4G. The location of the cre is thought to be within the 2C region. 

Genome organization and replication

Genome layout

VPg+5′-UTRIRES-IV-[L/1A-1B-1C-1D-2Anpgp/2B-2C/3A-3B-3C-3D]-3′-UTR-poly(A)

The deduced polyprotein varys from 2,199–2,236 aa. The function of the leader polypeptide is unknown. 2A is a short foot-and-mouth disease virus-like polypeptide with NPG↓P motif. 

Antigenicity

Porcine teschoviruses are divided into 13 types (PTV-1 to -13) which are distinct in cross-neutralization tests (where tested).

Biology

Clinical manifestations may include a polioencephalomyelitis (“Teschen/Talfan disease”, also known as teschovirus encephalomyelitis), which may vary in severity. The viruses have been associated with a number of disease syndromes, including reproductive and gastrointestinal disorders. Domestic pigs and wild boars are the only known hosts.

Species demarcation criteria

There is only a single species in the genus.

Member species

SpeciesVirus name(s)Exemplar isolateExemplar accession numberExemplar RefSeq numberAvailable sequenceOther isolatesOther isolate accession numbersVirus abbreviationIsolate abbreviation
Teschovirus Ateschovirus AF65AJ011380NC_003985Complete genomeTV-A
Teschovirus Ateschovirus A2; porcine teschovirus 2T80AF296087PTV-2
Teschovirus Ateschovirus A3; porcine teschovirus 3O 2bAF296088PTV-3
Teschovirus Ateschovirus A4; porcine teschovirus 4PS 36AF296089PTV-4
Teschovirus Ateschovirus A5; porcine teschovirus 5F 26AF296090PTV-5
Teschovirus Ateschovirus A6; porcine teschovirus 6PS 37AF296091PTV-6
Teschovirus Ateschovirus A7; porcine teschovirus 7F 43AF296092PTV-7
Teschovirus Ateschovirus A8; porcine teschovirus 8UKG/173/74AF296093PTV-8
Teschovirus Ateschovirus A9; porcine teschovirus 9Vir 2899/84AF296094PTV-9
Teschovirus Ateschovirus A10; porcine teschovirus 10Vir 460/88AF296095PTV-10
Teschovirus Ateschovirus A11; porcine teschovirus 11DresdenAF296086PTV-11
Teschovirus Ateschovirus A12; porcine teschovirus 12CC25 (Spain/2005)JF724001PTV-12
Teschovirus Ateschovirus A13; porcine teschovirus 13wild boar/WB2C-TV/2011/HUNJQ429405PTV-13

Virus names, the choice of exemplar isolates, and virus abbreviations, are not official ICTV designations.

Derivation of names

Tescho-: from Teschen disease; named after the Moravian-Silesian town Teschen (now Těšín at the Czech/Polish border.

Related, unclassified viruses 

Virus name

Accession number

Virus abbreviation

teschovirus [JPN/Ishi-Ka1/2015/G]

LC386154

 

teschovirus [JPN/Ishi-Ka2/2015/G]

LC386155

 

teschovirus [JPN/Ishi-Ta1/2016/G]

LC386156

 

teschovirus [JPN/Ishi-Ta2/2016/G]

LC386157

 

teschovirus [JPN/Ishi-Im1-1/2015/G]

LC386158

 

teschovirus [JPN/Mol2-2-1/2015/G]

LC386159

 

teschovirus [HuN41]

MG875515

 

teschovirus [HUN42]

MG875516

 

Virus names and virus abbreviations are not official ICTV designations.

Phylogenetic analysis indicates that these viruses may be members of a novel Teschovirus species.