Genus: Rosavirus

Genus: Rosavirus

Distinguishing features

The genus is distinguished on the basis of genetic characters. 



No details are available on the morphology of the virions. 

Nucleic acid

Genome (Du et al., 2016, Phan et al., 2011, Lim et al., 2014, Lau et al., 2016): c. 8,931 nt (5′-UTR: 504-721 nt; ORF: 7,410-7,449 nt; 3′-UTR: 712-946 nt). 5′-UTR harbours a type II IRES. 3′-UTR is the longest of picornaviruses. The location of the cre has not been identified.

Genome organization and replication

Genome layout:


The deduced polyprotein is of 2,468-2,491 aa. 2A has a H-box/NC motif. 


See discussion under family description.


Viral RNA was detected in faecal samples of humans and rodents [canyon mouse (Peromyscus crinitus), brown rat (Rattus norvegicus), black rat (R. rattus), Sikkim rat (R. andamanensis), chestnut white-bellied rat (Niviventer fulvescens)]. Available sequence data suggest 8 types.

 Species demarcation criteria

Members of a species of genus Rosavirus:

  • share a common genome organization,
  • are less than 30% divergent in the polyprotein aa sequence,
  • are less than 30% divergent in the P1 aa sequence,
  • are less than 25% divergent in the 2C + 3CD aa sequence.

Rosavirus A and Rosavirus B both include two genetic types, while Rosavirus C includes four genetic types. 

Member species

Exemplar isolate of the species
SpeciesVirus nameIsolateAccession numberRefSeq numberAvailable sequenceVirus Abbrev.
Rosavirus Arosavirus A1mouse/USA/M-7/2010JF973686NC_038880Complete coding genomeRoV-A1
Rosavirus Arosavirus A2hu/GA7403/Gambia/2008KJ158169Complete genomeRoV-A2
Rosavirus BNorway rat rosavirusRNCW0602091RKX783423NC_031105Complete genomeRoV-B
Rosavirus Crat rosavirusRASK8FKX783424Complete genomeRoV-C

Virus names, the choice of exemplar isolates, and virus abbreviations, are not official ICTV designations.

Derivation of names

Rosa-: from rodent stool-associated