Genus: Rabovirus


Genus: Rabovirus

Distinguishing features

The genus is distinguished on the basis of genetic characters.

Virion

Morphology

No details are available on the morphology of the virions.

Nucleic acid

Genome (Ng et al., 2015a): up to 7,834 nt (5′-UTR: up to 751 nt; ORF: 6,930-7,143 nt; 3′-UTR: 61-91 nt). The location of the cre has not been identified. 

Genome organization and replication

Genome layout:

VPg+5′-UTRIRES-II-[L/1A-1B-1C-1D/2Apro-2B-2C/3A-3B-3C-3D]-3′-UTR-poly(A)

The deduced polyprotein ranges from 2310 to 2381 aa. The L protein has unknown function. The 2A protein has been proposed to be a chymotrypsin-like protease. 

Antigenicity

See discussion under family description.

Biology

Viral RNA was detected in faeces of Norway rats (Rattus norvegicus) and mice (Mus musculus) in USA and Germany, in intestinal contents of Himalayan marmots (Marmota himalayana), and in tissue samples of Gairdner's shrewmice (Mus pahari). 

Species demarcation criteria

Members of a species of genus Rabovirus:

  • share a common genome organization,
  • are less than 30% divergent in the polyprotein aa sequence,
  • are less than 30% divergent in the P1 aa sequence,
  • are less than 25% divergent in the 2C + 3CD aa sequence.

Member species

SpeciesVirus name(s)Exemplar isolateExemplar accession numberExemplar RefSeq numberAvailable sequenceOther isolatesOther isolate accession numbersVirus abbreviationIsolate abbreviation
Rabovirus Arabovirus A1Berlin/Jan2011/0572KP233897NC_026314Complete genomeRaBoV-A1
Rabovirus Brabovirus B1RtMp-PicoV/YN2014KY432926Complete genomeRaBoV-B1
Rabovirus Crabovirus C1HT5KY855432NC_040605Complete genomeRaBoV-C1
Rabovirus Drabovirus D1MPV/NYC/2014/M005/0074MF175072Complete genomeRaBoV-D1

Virus names, the choice of exemplar isolates, and virus abbreviations, are not official ICTV designations.

Derivation of names

Rabo-: from rat-borne