Genus: Pasivirus


Genus: Pasivirus

Virion

Nucleic acid

Length of genome (Sauvage et al., 2012, Boros et al., 2015a, Yu et al., 2013): c. 6,938 nt (5'-UTR: c. 420 nt; ORF: c. 6,402 nt; 3' UTR: 136 nt). The location of the cre has not been identified.

Genome organization and replication

Genome layout:

VPg+5'UTRIRES-IV[1AB-1C-1D-2A1npgp/-2A2-2B-2C/3A-3B-3C-3D]3'UTR-poly(A)

The deduced polyprotein has a length of c. 2,133 aa. There is no L protein. 1AB protein remains uncleaved. The aphthovirus-like 2A1 protein has a NPG¯P sequence motif; the function of 2A2 is unknown. 3Dpol has a deviant ASG motif.

Antigenicity

See discussion under family description.

Biology

The natural host is likely the domestic pig (Sus scrofa). Viral RNA has been detected in faeces of pigs.

Species demarcation criteria

Members of a species of the genus Pasivirus:

  • share greater than 70% aa identity in P1,
  • share greater than 80% aa identity in 2C + 3CD,
  • share a common genome organization.

The divergence (number of differences per site between sequences) of known Pasivirus species ranges from 0.66-0.67 for P1 and 0.63-0.64 for 3CD. 

Three types have been classified by means of phylogenetic clustering.

Member species

SpeciesVirus name(s)Exemplar isolateExemplar accession numberExemplar RefSeq numberAvailable sequenceOther isolatesOther isolate accession numbersVirus abbreviationIsolate abbreviation
Pasivirus Apasivirus A; swine pasivirusswine/France/2011JQ316470NC_018226Complete genomePaV-A

Virus names, the choice of exemplar isolates, and virus abbreviations, are not official ICTV designations.

Derivation of names

Pasi: from parecho sister-clade