Genus: Mischivirus


Genus: Mischivirus

Distinguishing features

The genus is distinguished on the basis of genetic characters.

Virion

Morphology

No details are available on the morphology of the virions.

Nucleic acid

Genome (Wu et al., 2012, Kemenesi et al., 2015): c. 8,457 nt (5′-UTR: up to 1,407 nt; ORF: 6750-6,846 nt; 3′-UTR: up to 220 nt). 5′-UTR is exceptionally long. The location of the cre has not been identified. 

Genome organization and replication

Genome layout:

VPg+5′-UTRIRES-II- [L/1AB-1C-1D-2Anpgp/2B-2C/3A-3B-3C-3D] -3′-UTR-poly(A)

The deduced polyprotein is of 2,282 aa. There is likely a L protein. 2A is a short foot-and-mouth disease virus-like polypeptide with NPG↓P motif.

Antigenicity

See discussion under family description.

Biology

The natural host is likely the common bent-wing bat (Miniopterus schreibersii) and the groundleaf giant bat (Hipposideros gigas). Viral RNA was detected in pharyngeal and anal swabs of apparently healthy bats.

Species demarcation criteria

Members of a species of the genus Mischivirus:

  • are less than 30% divergent in polyprotein aa sequence,
  • are less than 30% divergent in P1 aa sequence,
  • are less than 25% divergent in 2C + 3CD aa sequence,
  • share a common genome organization.

Member species

SpeciesVirus name(s)Exemplar isolateExemplar accession numberExemplar RefSeq numberAvailable sequenceOther isolatesOther isolate accession numbersVirus abbreviationIsolate abbreviation
Mischivirus Amischivirus A; Minopterus schreibersii picornavirusbat/China/2010JQ814851NC_034381Complete genomeMiV-A
Mischivirus Bmischivirus B1; bat picornavirusbatPV/V1/13/HunKP054273NC_043072Complete genomeMiV-B1
Mischivirus Cmischivirus C1; African bat icavirusTNo13KP100644NC_026470Complete genomeMiV-C1
Mischivirus Dcanine picornavirusA128thrKY512802Complete genomeMiV-D

Virus names, the choice of exemplar isolates, and virus abbreviations, are not official ICTV designations.

Derivation of names

Mischi-: Miniopterus schreibersii (common bent-wing bat)