Genus: Hunnivirus


Genus: Hunnivirus

Virion

Morphology

No surface morphology is visible on the 28 nm particles by EM.

Nucleic acid

Length of genome (Reuter et al., 2012, Firth et al., 2014, Du et al., 2016): 7,496-7,588 nt (5'-UTR: 715-732 nt; ORF: 7,425 nt; 3'-UTR: 114-119 nt). 5' UTR contains a type II IRES. The location of the cre has not been identified.

Genome organization and replication

Genome layout:

VPg+5'UTRIRES-II[L-1A-1B-1C-1D-2Anpgp/2B-2C/3A-3B-3C-3D]3'UTR-poly(A)

The deduced polyprotein has a length of 2,474 aa. There is a L protein with unknown function. 2A is a short FMDV type A-like polypeptide with NPG¯P motif.

Antigenicity

See discussion under family description.

Biology

Viral RNA was detected in the faeces of cattle, sheep and rats. One virus (HuV-A3), from sheep, has been isolated in lamb kidney cell cultures in which it caused a CPE.

Species demarcation criteria

Members of a species of the genus Hunnivirus share a common genome organization.

The divergence (number of differences per site between sequences) of known Hunnivirus species ranges from 0.54-0.58 for P1 and 0.49-0.5 for 3CD. There are three genetic types, one found in cattle, two in sheep. Phylogenetic analyses suggest that hunniviruses from rats form a second species containing three genetic types.

Member species

SpeciesVirus name(s)Exemplar isolateExemplar accession numberExemplar RefSeq numberAvailable sequenceOther isolatesOther isolate accession numbersVirus abbreviationIsolate abbreviation
Hunnivirus Ahunnivirus A1; bovine hungarovirus cattle/HUN/2008JQ941880NC_018668Complete genomeHuV-A1

Virus names, the choice of exemplar isolates, and virus abbreviations, are not official ICTV designations.

Derivation of names

Hunni: from Hungary and Northern Ireland

Related, unclassified viruses 

Virus name

Accession number

Virus abbreviation

Hunnivirus 05VZ-75-RAT099

KT944214

 

Hunnivirus 83GR-70-RAT106

KT944212

 

Hunnivirus 83GR-70-RAT051

KT944201

 

Virus names and virus abbreviations are not official ICTV designations.