Genus: Hunnivirus


Genus: Hunnivirus

Distinguishing features

The genus is distinguished on the basis of genetic characters.

Virion

Morphology

No surface morphology is visible on the 28 nm particles by EM.

Nucleic acid

Genome (Reuter et al., 2012, Firth et al., 2014, Du et al., 2016): 7,496–7,588 nt (5′-UTR: 715–732 nt; ORF: 7,425 nt; 3′-UTR: 114–119 nt). 5′-UTR contains a type II IRES. The location of the cre has not been identified.

Genome organization and replication

Genome layout:

VPg+5′-UTRIRES-II-[L-1A-1B-1C-1D-2Anpgp/2B-2C/3A-3B-3C-3D]-3′-UTR-poly(A)

The deduced polyprotein is of 2,474 aa. There is a L protein with unknown function. 2A is a short foot-and-mouth disease virus-like polypeptide with NPG↓P motif.

Antigenicity

See discussion under family description.

Biology

Viral RNA was detected in the faeces of cattle, sheep and rats. One virus (HuV-A3), from sheep, has been isolated in lamb kidney cell cultures in which it caused a CPE. Up to 9 genetic types may circulate. 

Species demarcation criteria

There is only a single species in the genus.

Member species

SpeciesVirus name(s)Exemplar isolateExemplar accession numberExemplar RefSeq numberAvailable sequenceOther isolatesOther isolate accession numbersVirus abbreviationIsolate abbreviation
Hunnivirus Ahunnivirus A1; bovine hungaroviruscattle/HUN/2008JQ941880NC_018668Complete genomeHuV-A1
Hunnivirus Ahunnivirus A2; ovine hungarovirus 1sheep/HUN/2009HM153767HuV-A2
Hunnivirus Ahunnivirus A4; Norway rat hunnivirusrat/Rn/PicoV/SX2015-2KX156157HuV-A4

Virus names, the choice of exemplar isolates, and virus abbreviations, are not official ICTV designations.

Derivation of names

Hunni-: from Hungary and Northern Ireland

Related, unclassified viruses 

Virus name

Accession number

Virus abbreviation

Hunnivirus 05VZ-75-RAT099

KT944214

 

Hunnivirus 83GR-70-RAT106

KT944212

 

Hunnivirus 83GR-70-RAT051

KT944201

 

ovine hungarovirus [OHUV/2009/HUN]

HM153767

 

rodent hunnivirus [rodent/Rn/PicoV/SX2015-2]

KX156157

 

Norway rat hunnivirus [NrHuV/NYC-E21]

KJ950971

 

 Virus names and virus abbreviations are not official ICTV designations.

Phylogenetic analyses suggest that hunniviruses from rats may form a second species containing three genetic types.