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In contrast to other picornaviruses, the genome layout of dicipiviruses exhibits two ORFs separated by an intergenic region (IGR) that functions as an IRES to translate the second ORF. The IGR-IRES of the one described member of this genus, canine picodicistrovirus, shows no similarity to the equivalent region in members of the Dicistroviridae.
Virus has not yet been isolated.
Length of genome (Woo et al., 2012): c. 8,785 nt (5'-UTR: at least 982 nt; ORF1: 2,535 nt; IGR: 588 nt; ORF2: 4,221 nt; 3'-UTR: 549 nt). 5' UTR harbours an type II IRES whereas the IGR-IRES has similarities to the type I IRES of enteroviruses. The location of the cre has not been identified.
The predicted polyprotein have lengths of 845 aa (P1) and 1,407 aa (P2-P3), respectively. There is no L protein. P1 comprises four capsid proteins (1A-1D); 1A lacks a myristoylation signal. The function of the 2A protein is unknown.
Viral RNA was detected in the faeces of diseased and healthy dogs.
Cadici: from canine dicistronic
Dicipi: from dicistronic picorna
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