Genus: Dicipivirus


Genus: Dicipivirus

Distinguishing features

In contrast to other picornaviruses, the genome layout of dicipiviruses exhibits two ORFs separated by an intergenic region (IGR) that functions as an IRES to translate the second ORF. The IGR-IRES shows no similarity to the equivalent region in members of the Dicistroviridae.

Virion

Morphology

No details are available on the morphology of the virions.

Nucleic acid

Genome (Woo et al., 2012, Reuter et al., 2018): 8,785-8,838 nt (5′-UTR: 776-982 nt; ORF1: 2,535-2,757 nt; IGR: 588-591 nt; ORF2: 4,221-4,581 nt; 3′-UTR: 133-549 nt). 5′-UTR harbours an type II IRES whereas the IGR-IRES has similarities to the type I IRES of enteroviruses. The location of the cre has not been identified.

Genome organization and replication

Genome layout:

VPg+5′-UTRIRES-II-[1A-1B-1C-1D]-IGRIRES-I[2A-2B-2C/3A-3B-3C-3D]-3′-UTR-poly(A)

The predicted polyproteins are of 845-919 aa (P1) and 1,407-1,527 aa (P2-P3), respectively. There is no L protein. P1 comprises four capsid proteins (1A-1D); 1A lacks a myristoylation signal. The function of the 2A protein is unknown.

Antigenicity

See discussion under family description.

Biology

Viral RNA was detected in the faeces of diseased and healthy dogs and in faecal samples, blood and various tissues of northern white-breasted hedgehogs (Erinaceus roumanicus).

Species demarcation criteria

Based on available sequence data, preliminary species demarcation criteria were defined. Members of a species of genus Dicipivirus:

  • share a common, dicistronic genome organization,
  • share less than 30% aa diversity in the P1 (orf 1),
  • share less than 30% aa diversity in the non-structural proteins 2C + 3CD.

Member species

SpeciesVirus name(s)Exemplar isolateExemplar accession numberExemplar RefSeq numberAvailable sequenceOther isolatesOther isolate accession numbersVirus abbreviationIsolate abbreviation
Cadicivirus Acanine picodicistrovirus209JN819202NC_021178Complete genomeCaPd
Cadicivirus Bhedgehog dicipivirushedgehog/H14/2015/HUNMF188967NC_040611Complete genomeHeDV

Virus names, the choice of exemplar isolates, and virus abbreviations, are not official ICTV designations.

Derivation of names

Cadici-: from canine dicistronic

Dicipi-: from dicistronic picorna