Genus: Dicipivirus


Genus: Dicipivirus

Distinguishing features

In contrast to other picornaviruses, the genome layout of dicipiviruses exhibits two ORFs separated by an intergenic region (IGR) that functions as an IRES to translate the second ORF. The IGR-IRES of the one described member of this genus, canine picodicistrovirus, shows no similarity to the equivalent region in members of the Dicistroviridae.

Virion

Morphology

Virus has not yet been isolated.

Nucleic acid

Length of genome (Woo et al., 2012): c. 8,785 nt (5'-UTR: at least 982 nt; ORF1: 2,535 nt; IGR: 588 nt; ORF2: 4,221 nt; 3'-UTR: 549 nt). 5' UTR harbours an type II IRES whereas the IGR-IRES has similarities to the type I IRES of enteroviruses. The location of the cre has not been identified.

Genome organization and replication

Genome layout:

VPg+5'UTRIRES[1A-1B-1C-1D]-IGRIRES[2A-2B-2C/3A-3B-3C-3D]3'UTR-poly(A)

The predicted polyprotein have lengths of 845 aa (P1) and 1,407 aa (P2-P3), respectively. There is no L protein. P1 comprises four capsid proteins (1A-1D); 1A lacks a myristoylation signal. The function of the 2A protein is unknown.

Antigenicity

See discussion under family description.

Biology

Viral RNA was detected in the faeces of diseased and healthy dogs.

Species demarcation criteria

Not applicable

Member species

SpeciesVirus name(s)Exemplar isolateExemplar accession numberExemplar RefSeq numberAvailable sequenceOther isolatesOther isolate accession numbersVirus abbreviationIsolate abbreviation
Cadicivirus Acanine picodicistrovirus209JN819202NC_021178Complete genomeCaPd

Virus names, the choice of exemplar isolates, and virus abbreviations, are not official ICTV designations.

Derivation of names

Cadici: from canine dicistronic

Dicipi: from dicistronic picorna