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Virus has not yet been isolated.
Length of genome (Holtz et al., 2008, Kapoor et al., 2008, Blinkova et al., 2009, Cotten et al., 2014, Kapusinszky et al., 2012): c. 7,632-7,802 nt (5'-UTR: up to 1,361 nt; ORF: 6,366-6,402 nt; 3'-UTR: 75-93 nt). The location of the cre has not been identified.
The deduced polyproteins have lengths of 2,113-2,133 amino acids. There is no L protein. 2A is a short FMDV-like polypeptide (NPG¯P). Sequence data (e.g., JN867757, KM516909) suggest interspecies recombination (Kapusinszky et al., 2012).
Known natural hosts are humans and pigs. Viral RNA was detected in faeces and pharyngeal swabs of diseased and clinically healthy humans and pigs.
Members of a species of the genus Cosavirus:
The divergence (number of differences per site between sequences) of known cosaviruses ranges from 0.4-0.53 for P1 and 0.22-0.37 for 3CD.
Sequence data of capsid protein-encoding gene regions indicate at least 35 types within these species (CoSV-A1 to -A25, CoS-V-B1, tentative CoSV-C1, CoSV-D1 to -D5, CoSV-E1, -E2, CoSV-F1).
Establishment of Cosavirus C is pending due to incomplete virus sequences.
Cosa: from common stool-associated
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