Genus: Cosavirus

Genus: Cosavirus



Virus has not yet been isolated.

Nucleic acid

Length of genome (Holtz et al., 2008, Kapoor et al., 2008a, Blinkova et al., 2009, Cotten et al., 2014, Kapusinszky et al., 2012): c. 7,632-7,802 nt (5'-UTR: up to 1,361 nt; ORF: 6,366-6,402 nt; 3'-UTR: 75-93 nt). The location of the cre has not been identified. 

Genome organization and replication

Genome layout:


The deduced polyproteins have lengths of 2,113-2,133 amino acids. There is no L protein. 2A is a short FMDV-like polypeptide (NPG¯P). Sequence data (e.g., JN867757, KM516909) suggest interspecies recombination (Kapusinszky et al., 2012). 


See discussion under family description.


Known natural hosts are humans and pigs. Viral RNA was detected in faeces and pharyngeal swabs of diseased and clinically healthy humans and pigs.

Species demarcation criteria

Members of a species of the genus Cosavirus:

  • share greater than 65% aa identity in P1,
  • share greater than 90% aa identity in 2C + 3CD,
  • share a common genome organization.

The divergence (number of differences per site between sequences) of known cosaviruses ranges from 0.4-0.53 for P1 and 0.22-0.37 for 3CD.

Sequence data of capsid protein-encoding gene regions indicate at least 35 types within these species (CoSV-A1 to -A25, CoS-V-B1, tentative CoSV-C1, CoSV-D1 to -D5, CoSV-E1, -E2, CoSV-F1).

Member species

SpeciesVirus name(s)Exemplar isolateExemplar accession numberExemplar RefSeq numberAvailable sequenceOther isolatesOther isolate accession numbersVirus abbreviationIsolate abbreviation
Cosavirus Acosavirus A10553FJ438902NC_012800Complete genomeCoSV-A1
Cosavirus Bcosavirus B2663FJ438907NC_012801Complete genomeCoSV-B
Cosavirus Dcosavirus D15004FJ438908NC_012802Complete genomeCoSV-D1
Cosavirus Ecosavirus EAustralia/81FJ555055NC_012798Complete genomeCoSV-E
Cosavirus Fcosavirus FPK5006JN867758NC_034385Complete genomeCoSV-F

Virus names, the choice of exemplar isolates, and virus abbreviations, are not official ICTV designations.

Establishment of Cosavirus C is pending due to incomplete virus sequences.

Derivation of names

Cosa: from common stool-associated