Genus: Lymphocryptovirus

Genus: Lymphocryptovirus

Distinguishing features

The predicted amino acid sequences of members form a distinct lineage within the subfamily (Figure 1.Gammaherpesvirinae).

Virion

See discussion under family description.

Genome organization and replication

Well-characterised members (e.g. Epstein-Barr virus [EBV] in the species Human gammaherpesvirus 4) have a prominent series of direct repeats located internally within the genome.

Biology

Members have primates as hosts. EBV can infect B lymphocytes in culture, but infection is usually non-productive and can result in immortalization (Nilsson et al., 1971). EBV commonly causes glandular fever (infectious mononucleosis). B cells or their precursors are thought to be the site of latent infection in vivo (Arvin et al., 2007).

Species demarcation criteria

See discussion under family description.

Member species

Exemplar isolate of the species
SpeciesVirus nameIsolateAccession numberRefSeq numberAvailable sequenceVirus Abbrev.
Callitrichine gammaherpesvirus 3callitrichine gammaherpesvirus 3; marmoset lymphosarcoma virusCJ0149AF319782NC_004367Complete genomeClGHV3
Cercopithecine gammaherpesvirus 14cercopithecine gammaherpesvirus 14; African green monkey EBV-like virusNo entry in GenbankCeGHV14
Gorilline gammaherpesvirus 1gorilline gammaherpesvirus 1; herpesvirus gorillaMachiAJ581752Partial genomeGoGHV1
Human gammaherpesvirus 4human gammaherpesvirus 4; Epstein-Barr virusB95-8AJ507799NC_007605Complete genomeHuGHV4; EBV
Macacine gammaherpesvirus 4macacine gammaherpesvirus 4; rhesus lymphocryptovirusLCL8664AY037858NC_006146Complete genomeMcGHV4; RLV
Macacine gammaherpesvirus 10macacine gammaherpesvirus 10; cynomolgus macaque lymphocryptoviruspfe-lcl-E3KP676001Complete genomeMcGHV10
Panine gammaherpesvirus 1panine gammaherpesvirus 1; herpesvirus panAustinAJ581751NC_038859Partial genomePnGHV1
Papiine gammaherpesvirus 1papiine gammaherpesvirus 1; herpesvirus papio594SAJ581750Partial genomePaGHV1
Pongine gammaherpesvirus 2pongine gammaherpesvirus 2; herpesvirus pongoCP-81AJ581753NC_038860Partial genomePoGHV2

Virus names, the choice of exemplar isolates, and virus abbreviations, are not official ICTV designations.