Genus: Mardivirus

Genus: Mardivirus

Distinguishing features

The predicted amino acid sequences of members form a distinct lineage within the subfamily (Figure 1.Alphaherpesvirinae).


See discussion under family description.

Genome organization and replication

See discussion under family and subfamily description.


Members have birds as hosts, and are best known for their effects on domesticated poultry such as chickens. Marek’s disease virus (MDV in the species Gallid alphaherpesvirus 2) is highly contagious in chickens and is associated with malignancy. For MDV, gallid herpesvirus 3 (GaAHV3 in the species Gallid alphaherpesvirus 3) and turkey herpesvirus (HVT in the species Meleagrid alphaherpesvirus 1), production of infectious extracellular virus occurs in the feather-follicle epithelium.


Members may cross-react serologically.

Species demarcation criteria

See discussion under family description.

Member species

Exemplar isolate of the species
SpeciesVirus nameIsolateAccession numberRefSeq numberAvailable sequenceVirus Abbrev.
Anatid alphaherpesvirus 1anatid alphaherpesvirus 1; duck enteritis virus2085JF999965Complete genomeAnAHV1; DEV
Columbid alphaherpesvirus 1columbid alphaherpesvirus 1; pigeon herpesvirusHLJKX589235NC_034266Complete genomeCoAHV1; PHV
Gallid alphaherpesvirus 2gallid alphaherpesvirus 2; Marek's disease virusMd5AF243438NC_002229Complete genomeGaAHV2; MDV
Gallid alphaherpesvirus 3gallid alphaherpesvirus 3; gallid herpesvirus 3SB-1HQ840738Complete genomeGaAHV3
Meleagrid alphaherpesvirus 1meleagrid alphaherpesvirus 1; turkey herpesvirusFC-126 (Burmenester)AF291866NC_002641Complete genomeMeAHV1; HVT
Spheniscid alphaherpesvirus 1spheniscid alphaherpesvirus 1lib01004LT608135NC_033464Complete genomeSpAHV1

Virus names, the choice of exemplar isolates, and virus abbreviations, are not official ICTV designations.