Figure 1 Schematic representation of a particle of hepatitis delta virus.
Figure 2 Organization of the genome and antigenome of hepatitis delta virus. The genome, by definition, is the 1679-nucleotide RNA that is assembled into virions. During replication one also detects the antigenome, a species that is an exact complement of the genome. Both RNAs are circular in conformation and have the ability to fold into an unbranched rodlike structure via intra-molecular base pairing, with the locations of the ends as indicated. Each has a ribozyme, with the cleavage sites as indicated. The antigenome contains the ORF for the 195 amino acid small delta antigen. However, this protein is actually translated from a third RNA, one that is only about 900 nt long, linear in conformation, 5′-capped and 3′-polyadenylated.