Figure 1 (Left) Atomic rendering of a papillomavirus capsid. Derived from an image reconstruction from electron cryomicroscopy of bovine papillomavirus (BPV) at 9 Å resolution combined with coordinates from the crystal structure of small virus-like particles of the human papillomavirus 16 (HPV-16) L1 protein (from Modis et al. (2002). EMBO J., 21, 4754–4762). (Centre) Schematic diagram representing the 72 capsomers in a T=7 arrangement of a papillomavirus capsid. The icosahedral structure includes 360 VP1 subunits arranged in 12 pentavalent and 60 hexavalent capsomers. (Right) Negative contrast electron micrograph of human papillomavirus 1 (HPV-1) virions. The bar represents 100 nm.
Figure 2 Diagram of the bovine papillomavirus 1 (BPV-1) genome. The viral dsDNA (size in bp, origin of replication: ori) is indicated. The outer arrows indicate the protein-coding ORFs and their direction of transcription.
Figure 3 Comparison of genome organization for the viruses corresponding to the type species of each genus in the family Papillomaviridae. The circular dsDNA genomes have been linearized, with ori as the opening site (see Figure 2). Similar ORFs are indicated in similar colors. For abbreviations, see species lists in text.
Figure 4 Phylogenetic tree representing the sequences of 118 papillomaviruses. The phylogenetically informative region of the L1 ORF was used in a modified version of the Phylip version 3.572 and based on a weighted version of the neighbor-joining analysis. Accession numbers are listed in the tables. The tree was constructed using the Treeview program (R. Page, University of Glasgow).